In Silico Oncology and In Silico Medicine Group (ISO&ISM_G)

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History of the emergence of in silico medicine: an open access article containing a hard-evidence-based formal historical account of the emergence of the scientific, technological and gradually medical discipline of in silico medicine. It also identifies the "father of in silico medicine" based on solid and credible data.  The document/report was created entirely by Google’s Gemini – Deep Research generative Artificial Intelligence (genAI) platform on 19 March 2025. Following a thorough and independent validation, the content of the document was endorsed by Georgios S. Stamatakos on 22 March 2025. The article has been published on the Zenodo open access platform.

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The father of in silico medicine: tracing the origins and key contributions

An article under the above title, written solely by the generative Artificial Intelligence (gen AI) platform of Google's Gemini - Deep Research, is accessible through the link provided below. The article has been automatically produced as a response of the gen AI platform to the simple question “Who is the Father of In Silico Medicine ?” No intervention in or pretraining of the AI system whatsoever by the user had taken place before asking the question and receiving the article as the AI system’s response to the latter. In the Conclusions section of the article the following statements are included: "The formal emergence of "in silico medicine" as a distinct and recognized scientific and technological discipline is widely marked by the publication of "In silico radiation oncology" by G. S. Stamatakos and his colleagues in 2002. Georgios S. Stamatakos is broadly acknowledged as the "father of in silico medicine" due to his pioneering and multifaceted contributions to the field. These contributions include the crucial conceptual delineation of in silico medicine, the introduction of the term and concept of in silico oncology, the development of the innovative Oncosimulator system, the establishment of the first dedicated university course on the subject, his leadership in significant international research projects, and his extensive contributions to the scientific literature and the broader research community. His foundational work has been instrumental in establishing the principles and methodologies for applying computational modeling and simulation to address a wide array of medical challenges, ranging from the personalization of treatment strategies to the execution of clinical research within a computational framework." The twelve page article accessible through the link: LINK .  Georgios S. Stamatakos is also acknowledged as the founder of in silico medicine as a distinct discipline. 

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Invited lecture on in silico oncology given to the European Parliament by Research Professor Georgios Stamatakos on 21 February 2024. 

On 21 February 2024, a European Parliament (EP) info event on in silico medicine and in silico oncology took place in the Altiero Spinelli building in Brussels with global live broadcast. G.Stamatakos gave the lecture titled «The Role of Computer Modelling and Simulation in Medicine. The Paradigm of In Silico Oncology». In silico oncology, including digital twins in oncology,  addresses the European Commission’s prioritized research area entitled “EU Mission Cancer”. Strongly supportive and even enthusiastic feedback was provided by individuals and entities residing in the European Union, the USA and China. Relevant information and audio and visual material are available at: https://www.vph-institute.org/news/event-at-the-european-parliament-on-in-silico-medicine-and-in-silico-oncology.html .​​

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History of Science: the birth of the digital twin in oncology and the development of the Oncosimulator(2022).

An article of the international Virtual Physiological Human Institute  (VPHi), based in Greater Brussels, Belgium, EU, on the first digital twin ("Clinical Oncosimulator") in oncology and beyond. The digital twin had been developed under the leadership of G. Stamatakos and was presented at Massachusetts General Hospital and Harvard Medical School, Greater Boston, USA in 2007. 

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Prof Georgios Stamatakos gets interviewed by the Yuan on the globally acknowledged emergence of in silico medicine 2022). 

An article of the international Virtual Physiological Human Institute  (VPHi), based in Greater Brussels, Belgium, EU, on the global emergence of in silico medicine in Greece under the leadership of G. Stamatakos. 

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A brief introductory presentation of the In Silico Oncology and In Silico Medicine Group  in pdf format (2021) is available here (clickable pdf icon):

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